Syngeneic Mouse Models

Overview

Syngeneic mouse models engraft murine cancer cells into genetically identical mouse strains, faithfully recapitulating the complexity of cancer cells and their interactions with the immune system. Compared to human samples, syngeneic mouse models allow for well-controlled experiments and provide a rich resource for studying tumor immunity and immunotherapy response. We can provide various syngeneic mouse models such as brain, breast, bladder, colorectal, liver and lung cancer models to test the efficacy of immuno-oncology drugs and therapies according to customers' requirements. If you would like to find a partner, please contact us immediately.

Why Use Syngeneic Mouse Models in Oncology Research?

• Immunocompetence: Syngeneic mouse models have a fully functional immune system, allowing researchers to study the interaction between cancer cells and the immune system. This is important for understanding how tumors evade immune detection and for developing immunotherapy approaches.
• Tumor microenvironment: Syngeneic mouse models closely mimic the tumor microenvironment of human cancers, including interactions with stromal cells, blood vessels, and the extracellular matrix. This makes them valuable for studying tumor growth, invasion, and metastasis.
• Genetic similarity: Syngeneic mouse models are genetically identical or closely related to the host strain. Therefore, these models are easier to study the effects of specific genetic alterations on tumorigenesis and treatment response.
• Predictive value: Studies have shown that syngeneic mouse models can accurately predict the response of human tumors to various therapies. Therefore, these models are important tools for preclinical drug development and personalized medicine.
• Cost-effectiveness: Syngeneic mouse models are relatively easy to establish and maintain in the laboratory. Therefore, these models are a cost-effective option for studying cancer biology and testing new therapies.

What We Offer

If you need a cell line model that is not listed in the table above, please contact us immediately. We can investigate validating a model for you.

Do you have questions about which syngeneic tumor model should be used for your research? Please contact us immediately and our team will help you achieve your goals.