- Overview
- Our Capabilities
- FAQs
Overview
In vivo pharmacology is a branch of pharmacology that focuses on the study of complex physiological effects of drugs in living organisms. The term "in vivo" refers to experiments conducted within a living organism, contrasting with "in vitro" experiments conducted outside of living organisms, typically in laboratory settings. In vivo pharmacology studies play a crucial role in drug development, providing preclinical data to support the identification, optimization, and clinical translation of new drugs and therapeutic interventions.
As a service provider specializing in in vivo pharmacology, we are committed to providing our clients with one-stop solutions to meet their unique needs. Our experienced pharmacologists have built a complete library of animal models based on accurate, efficient drug efficacy testing. The model library helps to study the pathogenesis of the disease, test potential therapeutic interventions, and evaluate drug efficacy.
Our Capabilities
Our team has created a combination of models covering a variety of disease indications to support your project research. The disease models we can provide are mainly as follows:
CNS Disorder Models
- Neurodegenerative disease models
- Psychiatric disorder models
- Epilepsy models
- Stroke models
- Traumatic brain injury (TBI) models
Autoimmune and Inflammation Models
- Rheumatoid arthritis (RA) models
- Multiple sclerosis (MS) models
- Delayed type hypersensitivity (DTH) models
- Psoriasis models
- Acute inflammation models
- Gout models
- Sepsis models
Cardiovascular Disease Models
- Thrombosis models
- Hypertension models
- Stroke models
- Heart failure models
Kidney Disease Models
- Acute kidney injury models
- Nephrotic syndrome models
- Chronic kidney disease models
- Diabetic kidney disease (DKD) models
Tumor Models
- Cell line-derived xenograft (CDX) tumor models
- Patient-derived xenograft (PDX) tumor models
- Syngeneic mouse models
- Orthotopic models
- Humanized mouse models
Frequently Asked Questions (FAQs) About In Vitro Biology
What types of experiments are conducted in in vivo pharmacology?
In vivo pharmacology experiments involve assessing drug efficacy, safety, pharmacokinetics, and pharmacodynamics in animal models of disease or healthy subjects. These experiments may include drug administration, physiological measurements, behavioral assessments, and tissue analysis.
How are animal models selected for in vivo pharmacology studies?
Animal models are selected based on their relevance to the disease or condition being studied and their suitability for assessing specific drug effects. Factors such as genetic similarity, physiological characteristics, disease phenotype, and ethical considerations are taken into account when choosing animal models.
How do in vivo pharmacology studies contribute to drug development?
In vivo pharmacology studies provide essential preclinical data to support the identification, optimization, and development of new drugs. These studies help assess the therapeutic potential, safety profile, and mechanism of action of drug candidates, guiding decision-making in drug development.
How do in vivo pharmacology findings translate to clinical trials?
Preclinical data from in vivo pharmacology studies inform the design and conduct of clinical trials in humans. Efficacy, safety, and pharmacokinetic data obtained from animal models help researchers optimize dosing regimens, identify potential risks, and evaluate therapeutic outcomes in clinical trials.
What disease areas can be researched with in vivo pharmacology studies?
In vivo pharmacology studies cover a wide range of disease areas, including central nervous system disorders, autoimmune and inflammation, cardiovascular diseases, kidney diseases, tumors, infectious diseases, respiratory diseases, and rare diseases.