Patient-Derived Xenograft (PDX) Tumor Models

Overview

Patient-derived xenograft (PDX) tumor models involve implanting fragments of patient-derived tumor tissue into immunocompromised mice, allowing the tumor to grow and be studied in a more controlled environment. These models are valuable tools for studying tumor biology, drug screening, and personalized medicine approaches, because they are superior to traditional tumor models in reflecting cancer characteristics and simulating the progression and evolution of tumors in human patients. Currently, we have thousands of PDX tumor models covering the full range of cancer types. If you would like to find a partner, please contact us immediately.

Advantages of the PDX Tumor Model

• The PDX tumor model has shown advantages in recapitulating the characteristics of cancer, such as the spatial structure of cancer and the intratumor heterogeneity of cancer.
• The PDX tumor model retains the genomic characteristics of patients with different stages, subtypes and diversified treatment backgrounds.
• Optimized PDX engraftment procedures and modern technologies such as multi-omics and deep learning help to improve the utilization of PDX tumor models.

The above advantages make PDX tumor models an ideal choice in cancer treatment research and are expected to effectively connect non-clinical and clinical data in translational research.

Applications of the PDX Tumor Model

Some common applications of the PDX tumor model include:

• Drug screening and development: PDX models can be used to study the efficacy of new anti-cancer drugs or drug combinations. Researchers can test the response of different tumors to various treatments, helping to identify potential therapeutic targets and personalized treatment strategies.
• Biomarker discovery: PDX models can be used to identify biomarkers associated with drug sensitivity or drug resistance. This information can help guide treatment decisions and improve patient outcomes.
• Tumor heterogeneity and evolution: PDX models can provide valuable insights into tumor heterogeneity and clonal evolution, helping researchers understand how tumors evolve and adapt to therapy. This information can be used to develop more effective treatment strategies and overcome drug resistance.
• Preclinical research: PDX models are commonly used in preclinical studies. By studying tumors in a more physiologically relevant environment, researchers can better understand cancer progression and identify new therapeutic targets.
• Personalized medicine: PDX models can be used to develop personalized treatment plans for individual patients based on the specific characteristics of their tumor. By testing the response of a patient's tumor to different treatments in a PDX model, oncologists can tailor therapy for patients to maximize effectiveness and minimize side effects.

What We Offer

We mainly provide PDX tumor models for the following cancer types:

Do you have questions about which PDX tumor model should be used for your research? Please contact us immediately and our team will help you achieve your goals.