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Oligonucleotide Modification

  • Overview
  • Our Services
  • Why Need Our Services
  • Our Advantages

Overview

Oligonucleotides can be chemically modified in order to enhance their specific properties and functions. Such modifications can alter the solubility, stability, affinity, and targeting of oligonucleotides, thereby broadening their potential for biomedical research and clinical applications. Our company is committed to providing you with a comprehensive range of oligonucleotide modification services. We have a variety of modification types for you to choose from. Below are the most common types:

  • Spacers
  • Linkers
  • Modified Bases
  • Fluorophores
  • Quenchers
  • Other Modifications

Our Services

  • General Modifications
  • Single Labeling
  • Dual/Multiple Labeling

General Modifications

5'-Modifications
  • 5' Acrydite
  • 5' Azide (N3)
  • 5' BIO-TEG
  • 5' Biotin
  • 5' C6-NH2
  • 5' C7-NH2
  • 5' CHCH
  • 5' CHO
  • 5' Cholesteryl
  • 5' COOH
  • 5' DBCO
  • 5' Digoxin
  • 5' ET-ROX
  • 5' ET-TAMRA
  • 5 'Ferrocene
  • 5' PET
  • 5' Phosphorylation
  • 5' SH
  • 5' Spacer 18
  • 5' Spacer C3
  • 5' SS
3'-Modifications
  • 3' Azide (N3)
  • 3' Biotin
  • 3' Biotin-TEG
  • 3' C3-FAM
  • 3' C7-NH2
  • 3' CHCH
  • 3' Cholesteryl
  • 3' DBCO
  • 3' Digoxin
  • 3' Ferrocene
  • 3' Phosphorylation
  • 3' SH
  • 3' Spacer C3
  • 3' SS
Internal Modifications
  • 5F-dU
  • 2-F-rA/C/G/U
  • 2'-O-Methyl -A/C/G/U
  • C7-NH2
  • deoxyInosine (dI)
  • deoxyUridine (dU)
  • dSpacer
  • dT-Azide
  • dT-Biotin
  • dT-DBCO
  • dT-Digoxin
  • dT-Ferrocene
  • LNA-A/C/G/T
  • Phosphorothioate
  • Spacer 12
  • Spacer 18
  • Spacer 9
  • Spacer C12
  • Spacer C3
  • Spacer C6

Single Labeling

  • Fluorophores
Fluorophores3'-5'-Designated SitesExcitation Maximum (nm)Emission Maximum (nm)
FAM√√√494518
TET√√√521536
JOE√√√520548
VIC√538554
HEX√√√535556
Quasar 570√√√547570
Cy3√√√552570
TAMRA√√√565580
ROX√√√585605
Texas Red√√√595615
Cy5√√√643667
Quasar 670√√647667
Cy5.5√√√684710
  • Quenchers
Quenchers3'-5'-
BHQ-1√√
BHQ-2√√
BHQ-3√
Eclipse√
Dabcyl√√
MGB√

Dual/Multiple Labeling

FluorophoresQuenchers
5'6-FAM3' BHQ-1
3' Eclipse
3' Dabcyl
5' TET3' BHQ-2
3' Dabcyl
5' HEX3' BHQ-1
3' BHQ-2
3' Dabcyl
5' TAMRA3' Eclipse
3' BHQ-1
3' BHQ-2
3' Dabcyl
5' ROX3' Eclipse
3' BHQ-1
3' BHQ-2
3' Dabcyl
5' CY53' BHQ-1
3' BHQ-2
3' BHQ-3
3' Dabcyl
5' CY33' BHQ-2
5' JOE3' Eclipse
3' BHQ-1
3' BHQ-2
3' Dabcyl
5' Texas Red3' BHQ-2

Why Need Our Services

For Drug Research and Development

Chemical modification helps to enhance the binding force of oligonucleotides to targets, thereby improving the activity and selectivity of drugs.

For Gene Therapy and Genetic Diagnosis

The introduction of specific modified groups helps to enhance the internal stability, cell membrane permeability and nuclease resistance of oligonucleotides, thereby improving their delivery efficiency in gene therapy and the accuracy of gene diagnosis.

Our Advantages

  • Diversified Modification Types: We have more than 100 modification groups for you to choose from.
  • Strict Quality Control: Our oligonucleotide chemical modification products meet QC and QA standards, and the average mutation rate of large-scale sequencing verification is less than 1/1000.
  • Multiple Purification Options: Our purification methods include but are not limited to desalt, PAGE, PAGE Plus, RP-HPLC, IE-HPLC and Dual HPLC.
  • Technical Support: We have a professional technical team that can provide you with any technical support related to oligonucleotide modification.
Online Inquiry

If you have any questions about our company, please use the form below to contact us.

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