- Overview
- Importance
- Our Capabilities
- Our Advantages
Overview
In vitro ADME (absorption, distribution, metabolism, and excretion) studies are experiments conducted during the early stages of drug discovery and development to assess the pharmacokinetic properties of potential drug candidates. Our company is a leader in the field of drug metabolism and pharmacokinetics (DMPK) research. We are committed to providing customers with a range of in vitro ADME services that ensure streamlined drug discovery and development.
Why Are in Vitro ADME Studies Important?
In vitro ADME studies provide valuable information on the pharmacokinetic properties of drug candidates, which can help identify potential issues early in the drug development process and guide the selection of lead compounds for further evaluation in preclinical and clinical studies. These studies contribute to the optimization of drug candidates for improved efficacy, safety, and overall success in clinical development.
Our Capabilities
Absorption
We investigate the drug's absorption process by evaluating key factors like permeability and solubility. Our capabilities are as follows:
- Permeability assays: Measure the ability of a compound to pass through cellular membranes, typically using cell monolayers such as Caco-2 cells.
- Solubility assays: Determine the solubility of the compound in various media to predict its dissolution and absorption behavior.
Distribution
We used in vitro distribution studies to investigate the distribution of drug candidates in body's tissues and organs. Our capabilities are as follows:
- Plasma protein binding assays: Determine the degree of binding of the drug to the protein in the bloodstream, and the degree of binding can affect the pharmacokinetic and pharmacodynamic parameters of the drug.
- Blood-brain barrier (BBB) permeability assays: Assess the ability of a compound to cross the BBB, which is critical for drugs targeting the central nervous system.
Metabolism
We used in vitro metabolism studies to examine how the drug candidate is metabolized. These studies provide insights into the metabolic stability and routes of metabolism of the drug candidate. Our capabilities are as follows:
- Hepatocyte metabolism assays: Use liver cells (hepatocytes) to assess the metabolic stability and routes of metabolism of the compound.
- Microsomal metabolism assays: Use liver microsomes to study the cytochrome P450-mediated metabolism of the compound.
Excretion
We used in vitro drug excretion studies to simulate the excretion process of drugs in vivo. This helps to evaluate the clearance rate of the drug in the body and understand the excretion characteristics of the drug in patients with kidney disease. Our capabilities are as follows:
- Renal clearance assays: Measure the rate at which the kidneys remove a drug from the blood and excrete it from the body through the urine.
Our Advantages
Unrivaled Expertise
Our team consists of highly skilled scientists with extensive experience in DMPK research. We offer not just theoretical expertise, but practical experience in conducting these specialized assays.
State-of-the-Art Infrastructure
Our laboratories are equipped with cutting-edge technology for precise studies. This assists in delivering fast, reliable, and comprehensive in vitro ADME studies.
High-quality Standards
Our company prides itself on maintaining high-quality standards, strictly adhering to relevant norms, guidelines, and ethical practices. We ensure that all experiments are strictly executed and yield accurate results.
High Client Satisfaction
We prioritize client satisfaction above all else and strive to exceed our clients' expectations in every aspect of our work. We maintain open communication, provide regular updates, and ensure that our clients are fully informed and satisfied with the progress and outcomes of their projects.