- Overview
- Why Use Orthotopic Models
- What We Offer
Overview
Orthotopic models are a powerful tool in cancer research for investigating tumor biology, metastasis, and therapeutic strategies in a physiologically relevant context. They have higher clinical relevance than subcutaneous xenograft models. Our company is committed to providing a wide range of orthotopic tumor models to support your research needs. If you would like to find a partner, please contact us immediately.
Why Use Orthotopic Models in Oncology Research?
- Replicating tumor location and microenvironment: Orthotopic models involve implanting tumor cells in the organ or tissue from which they originated, allowing researchers to study the tumor growth within its natural microenvironment. This provides valuable insights into the study of tumor-stroma interactions, angiogenesis, invasion, and metastasis.
- Predicting therapeutic response: Orthotopic models can better predict how tumors respond to treatment compared to subcutaneous models. This is important for developing and testing new cancer treatments.
- Studying metastasis: Orthotopic models can also be used to study cancer metastasis, as tumors are grown in the same organ or tissue where metastases typically occur. This allows researchers to better understand the mechanisms of metastasis and develop strategies to prevent or treat it.
- Imaging research: Orthotopic models are compatible with a variety of imaging modalities, such as MRI, PET, CT, and bioluminescence imaging, which allows researchers to monitor tumor growth, metastasis, and treatment response in living animals non-invasively. This facilitates longitudinal studies and enables the assessment of treatment effects on both primary tumors and metastatic lesions.
What We Offer
Human Cell Line Models
| Cancer Type | Available Cell Lines |
| Brain cancer | U87MG |
| Breast cancer | MCF-7, SK-BR-3, MDA-MB231 |
| Colorectal cancer | Caco-2, COLO 205, Difi, DLD-1, HCC-2998, HCT 116, HT-29, KM12, KM20L2, LS-174T, RKO, SW480, SW620 |
| Leukemia | ARH-77, CCRF-CEM, HEL92.1.7, HL-60, K562-CD19, Kasumi-1, KG-1, KG-1a, MEC-1, MEG-01, MOLM-13, MOLT-4, MV4-11, NALM-6, NOMO-1, OCI-AML2, OCI-AML3, RS4;11, THP-1 |
| Liver cancer | SK-HEP-1 |
| Lung cancer | SHP-77 |
| Lymphoma | JURKAT, K-562, Mino, Namalwa, RajiB, RL, U937 |
| Melanoma | A375 |
| Ovarian cancer | OVCAR-3, A2780 |
| Prostate cancer | PC-3, PC3M |
Murine Cell Line Models
| Cancer Type | Available Cell Lines |
| Brain cancer | GL261 |
| Breast cancer | 4T1-luc |
| Lung cancer | LL |
| Lymphoma | A20, L1210 |
| Melanoma | B16F10 |
If you need a cell line model that is not listed in the table above, please contact us immediately. We can investigate validating a model for you.
Do you have questions about which orthotopic model should be used for your research? Please contact us immediately and our team will help you achieve your goals.