- Overview
- Our Capabilities
- FAQs
Overview
Compared with traditional methods, structure based drug design is becoming a tool for faster, more economical and more successful lead discovery. This approach is based on an understanding of the drug's three-dimensional structure and how its shape and charge cause it to interact with biological targets, ultimately eliciting a medical effect. Our company is committed to designing and optimizing the chemical structure for you to identify drug candidates suitable for clinical trials.
Our Capabilities
We are equipped with advanced laboratories and sophisticated equipment to provide one-stop services for structure based drug discovery. Our capabilities are mainly as follows:
Biophysical Assays
- Surface plasmon resonance (SPR)
- Thermal shift assay (TSA)
- Isothermal titration calorimetry (ITC)
- Microscale thermophoresis (MST)
X-Ray Crystallography Services
- Gene to structure services
- Protein cloning, expression and purification
- Biophysical characterization using dynamic light scattering (DLS), circular dichroism (CD) spectroscopy, differential scanning fluorimetry (DSF), nuclear magnetic resonance (NMR) spectroscopy
- Crystallization, X-ray data collection and structure determination
- Protein-ligand co-crystallization and structure determination
- Custom services
- Initial screening only
- Crystal optimization only
- Data collection only
- Structure solution only
- Refinement only
- Other services
- Over 200 relevant targets available for protein-ligand-structure determination
- Save your time with predefined protein production, purification, analysis and crystallization
Cryo Electron Microscopy (Cryo-EM) Services
- Structure determination of a single protein
- Structure determination of protein complex
- Structure determination of membrane protein
Fragment-Based Drug Discovery
- Fragment library design and screening
- Hit validation and characterization
- Lead optimization
Frequently Asked Questions (FAQs) About Structure Based Drug Discovery
How does structure based drug discovery differ from other approaches to drug discovery?
Unlike traditional methods, structure based drug discovery starts with an understanding of the target's atomic-level structure and mechanism of action, allowing for rational design of compounds that fit into the target's active site or modulate its function effectively. This allows for a more rational and targeted approach to drug design.
What are the advantages of structure based drug discovery?
Structure based drug discovery allows rational drug design. It also facilitates the optimization of drug candidates to improve pharmacokinetic properties and reduce off-target effects.
What types of targets can be studied using structure based drug discovery?
Structure based drug discovery can be applied to a wide range of biological targets, including enzymes, receptors, ion channels, and nucleic acids. These targets may be implicated in various diseases, such as cancer, infectious diseases, neurodegenerative disorders, and metabolic disorders.
What techniques are typically used in structure based drug discovery?
Common techniques used in structure based drug discovery include X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and computational modeling. These techniques allow researchers to determine the three-dimensional structure of a target and design drugs that can interact with it.
How successful is structure based drug discovery in developing new drugs?
Structure based drug discovery has been successful in developing many clinically approved drugs, particularly in the field of protein kinases and G protein-coupled receptors. These drugs include HIV protease inhibitors, kinase inhibitors for cancer therapy, and neuraminidase inhibitors for influenza treatment.