- Overview
- Why Use Humanized Mouse Models
- What We Offer
Overview
Humanized mice are immunodeficient mice co-engrafted with human tumors and immune components, which offer advantages for immuno-oncology research [1]. Humanized mouse models have become groundbreaking tools for studying human diseases and developing new therapeutic strategies. We have successfully constructed and validated a series of humanized mouse models that are invaluable in understanding the complex mechanisms of cancer and testing potential treatments.
Why Use Humanized Mouse Models in Oncology Research?
- Relevance to Human Biology: Humanized mouse models contain functional human immune systems. This allows researchers to study tumor-immune interactions in a physiologically relevant context, including tumor infiltration by immune cells, tumor evasion of immune surveillance, and immune-mediated tumor destruction.
- Personalized Medicine: Patient-derived xenograft (PDX) models allow the implantation of patient tumor tissue into humanized mice. These models retain the genetic and histological characteristics of the original patient tumors and provide a platform for evaluating individualized therapeutic strategies.
- Drug Development and Screening: Humanized mouse models are used to screen potential anticancer drugs and to evaluate drug efficacy, pharmacokinetics, and toxicity in a humanized immune system. This enables researchers to identify promising drug candidates for further preclinical and clinical development.
What We Offer
| Humanized CD34+ (huCD34) Mouse Models | Humanized CD34+ mouse models are created by transplanting human CD34+ hematopoietic stem and progenitor cells (HSPCs) into immunodeficient mice, usually of the NSG (NOD-scid IL2Rγnull) or NOG (NOD/Shi-scid/IL-2Rγnull) strains. The model is characterized as follows:
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| Humanized PBMC (huPBMC) Mouse Models | Human peripheral blood mononuclear cells (PBMCs) were injected into immunodeficient mice to form a humanized PBMC mouse model. The model is characterized as follows:
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| Knock-in Humanized Mouse Models | In knock-in humanized mouse model, mouse genes are replaced with human counterparts. The model can express human targets, so a synthetic model can be used to test the response of immune checkpoint inhibitors. |
Do you have questions about which humanized mouse model should be used for your research? Please contact us immediately and our team will help you achieve your goals.
Reference
- Chuprin, J.; et al. Humanized mouse models for immuno-oncology research. Nature Reviews Clinical Oncology. 2023, 20(3): 192-206.