- Overview
- Role of Metabolite Identification
- Our Capabilities
- Our Technology Platform
- Our Advantages
Overview
Metabolite identification plays a key role in drug discovery and development, providing valuable insights into the metabolic fate of drug candidates within living organisms. With years of experience in the field of drug metabolism, our company has become an industry leader. We are committed to providing customers with professional metabolite identification services. Contact us today if you are in need.
Role of Metabolite Identification
Toxicity Prediction
Metabolite identification plays a critical role in predicting the potential toxicity of drug candidates. By elucidating metabolic pathways and identifying reactive metabolites or metabolites with adverse effects, researchers can assess the safety profile of compounds early in the development process.
Drug Interaction Assessment
Metabolite identification helps identify shared metabolic pathways and potential interactions between multiple drugs. By characterizing metabolite profiles and metabolic enzymes involved, researchers can anticipate and mitigate the risk of adverse interactions, ensuring the safe and effective use of combination therapies.
Pharmacokinetic Profiling
Metabolite identification provides valuable insights into the pharmacokinetic properties of drug candidates, including absorption, distribution, metabolism, and excretion (ADME). By characterizing metabolite profiles and metabolic pathways, researchers can optimize dosing regimens, predict systemic exposure, and assess bioavailability.
Structural Elucidation
Metabolite identification helps elucidate the chemical structure of metabolites generated during drug metabolism. Advanced analytical techniques, such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, are used to analyze metabolite profiles and determine their chemical compositions. Structural elucidation of metabolites provides valuable insights into their properties and potential biological activities, guiding further research and development efforts.
Our Capabilities
In Vitro Metabolite Identification
- Metabolic soft spot analysis and identify
- Reactive metabolite trapping
- Metabolite identification in liver microsomes
- Metabolite identification in hepatocyte
- In vitro metabolite identification in plasma or blood
In Vivo Metabolite Identification
- Metabolite identification in animal samples (samples include plasma, blood, urine, feces, bile, tissue, etc.)
- Metabolite identification in human samples (samples include plasma, urine, feces, etc.)
Our Technology Platform
We utilize state-of-the-art analytical technologies to accurately analyze and identify metabolites. Our key technologies are listed below:
- MS: MS is a powerful analytical technique used in metabolite identification. High-resolution mass spectrometry (HRMS) coupled with tandem mass spectrometry (MS/MS) allows for accurate determination of metabolite structures based on their mass-to-charge ratios and fragmentation patterns.
- NMR Spectroscopy: NMR spectroscopy provides valuable structural information about metabolites by analyzing their nuclear spins. It is particularly useful for elucidating the chemical structure and configuration of metabolites, complementing mass spectrometry data.
Our Advantages
Unparalleled Expertise and Experience
We have a team of experienced scientists and specialists with extensive knowledge and experience in metabolite identification. Our track record of success in delivering high-quality results speaks volumes about our capabilities.
Timely Delivery
We are committed to delivering timely and reliable results to our clients. Our efficient project management process and streamlined workflow allows us to expedite our services, saving our clients valuable time and resources.
Comprehensive Services
We offer a comprehensive suite of services in metabolite identification. Whether it's in vitro metabolism studies, in vivo pharmacokinetic profiling, or structural elucidation of metabolites, we provide tailored solutions to meet our clients' specific needs.