- Overview
- Advantages
- Our Capabilities
- Production Flow
- Our Advantages
Overview
Oligonucleotides are short single-stranded or double-stranded DNA or RNA molecules with a length of 8-50 nucleotides, which enhance or repress the expression of target RNA through Watson-Crick base pairing. Oligonucleotides can be precisely tailored to selectively bind complementary sequences in genes, mRNAs, or other nucleic acids. This ability makes them key molecules in driving innovation in areas such as pharmaceuticals, diagnostics and genetic research.
Advantages of Oligonucleotide Drugs
Compared with traditional small molecule drugs and biologics, oligonucleotide drugs have many advantages. These advantages make them attractive candidates for the treatment of various rare diseases. The main advantages are as follows:
High Specificity
One of the advantages of oligonucleotide drugs is their high specificity, which is the result of sequence-specific base pairing of target RNA. This high specificity minimizes off-target effects and reduces the risk of unintended interactions with non-targeted molecules, thereby improving safety.
Abundant Candidate Targets
In theory, any disease caused by the wrong expression of a particular gene can be treated with oligonucleotide drugs. This provides a wealth of candidate targets for the development of oligonucleotide drugs, making them break through the limitations faced by traditional small molecule drugs and antibody drugs.
Longer Duration of Action
Some oligonucleotide drugs exhibit prolonged duration of action due to their stability and persistence in target tissues. This feature gives oligonucleotide drugs a competitive advantage in the field of chronic diseases such as diabetes and cardiovascular disease.
Our Capabilities
Our company provides one-stop oligonucleotide manufacturing services. Our capabilities are as follows:
RNA Synthesis
- Small interference RNA (siRNA)
- MicroRNA (miRNA)
- CRISPR RNA (crRNA)
- Single guide RNA (sgRNA)
- Small activating RNA (saRNA)
DNA Synthesis
- Antisense oligonucleotides (ASO)
- Aptamer
- Vaccine adjuvant
Conjugated Oligonucleotides Synthesis
- Small molecule conjugated oligonucleotides
- GalNAc conjugated oligonucleotides
- Peptide conjugated oligonucleotides
- Lipid and PEG conjugated oligonucleotides
- AOC (antibody-oligo conjugate)
Production Flow
Our Advantages
- Strong Manufacturing Capability: Microgram to kilogram-scale synthesis specifications to meet your needs from R & D level to manufacturing level.
- Strict Quality Control: Strictly control the quality of products under the requirements of ISO9001 quality system.
- Quality Analysis: Q-TOF, UPLC-MS, UPLC, GPC and other perfect analysis facilities to ensure quality.
- High Customization: A wide range of modification types and flexible synthetic specifications are available.