- Overview
- Advantages of FBDD
- Our Services
- Why Choose Us
Overview
Fragment-based drug discovery (FBDD) is a strategic approach to drug discovery that focuses on identifying small, low-molecular-weight fragments as starting points for developing high-affinity lead compounds. This approach requires the screening of fewer compounds than traditional high-throughput screening (HTS) methods and provides a more efficient and fruitful optimization campaign. Our company offers clients a comprehensive suite of FBDD services covering every stage of the drug discovery process. If you are interested in our services, please contact our experts today. Let's work together to further develop your project.
Advantages of FBDD
- Increased Hit Rates: FBDD typically yields higher hit rates compared to traditional HTS methods, as fragment libraries are designed to target specific binding sites with greater chemical diversity.
- Efficient Use of Resources: FBDD focuses on identifying low-molecular-weight fragments, which require fewer resources for synthesis and optimization compared to larger compounds.
- Targetability of Protein-Protein Interactions: Studies have shown that aberrant protein-protein interactions (PPIs) are associated with a wide range of diseases, including cancer, infectious diseases, and neurodegenerative disorders. FBDD is the optimal approach for PPIs modulators designing because PPI interface is usually composed of discontinuous hot-spots.
Our Services
Fragment Library Design and Screening
- Fragment Library Design: Our experts can curate or design for you a diverse library of small organic molecules, typically ranging in size from 150 to 300 Dalton, based on criteria such as diversity, drug-likeness and chemical space coverage.
- Biophysical Screening: Our state-of-the-art screening platforms utilize techniques such as nuclear magnetic resonance (NMR) spectroscopy, surface plasmon resonance (SPR), X-ray crystallography, and thermal shift assay (TSA) to screen fragment libraries against the target protein.
Hit Validation and Characterization
- Hit Confirmation: We validate and confirm fragment hits through secondary assays to assess binding affinity, specificity, and functional activity.
- Biophysical and Structural Analysis: Our experts perform detailed biophysical and structural characterization of fragment hits to elucidate their binding mode, interaction sites, and structural features critical for potency and selectivity.
Lead Optimization
- Lead Compound Identification: We identify and optimize lead compounds through iterative cycles of chemical synthesis, structure-activity relationship (SAR) analysis, and biological evaluation.
- Structure-Guided Design: Our team utilizes structural information obtained from fragment screening and hit characterization to guide rational design strategies, facilitating lead optimization and structure-based drug design (SBDD) approaches.
Why Choose Us
Expertise and Experience
Our company boasts a team of highly skilled scientists, chemists, and biophysicists with extensive experience in FBDD and drug discovery.
State-of-the-Art Facilities
Our company is equipped with state-of-the-art instrumentation and platforms for fragment screening, hit validation, structural characterization, and lead optimization. We leverage advanced biophysical and computational techniques, including NMR spectroscopy, SPR, X-ray crystallography, and molecular modeling, to deliver high-quality results.
Comprehensive Services
Our company offers a full spectrum of FBDD services, from fragment library design and screening to lead optimization and preclinical development. We tailor our services to meet the specific needs and objectives of each client.
Timely Delivery
Our company employs efficient workflows to ensure timely delivery of results. Our team maintains open communication with our clients, providing regular updates, progress reports and expert guidance throughout the FBDD project.