- Overview
- Significance
- Important Parameters of PK
- Our Capabilities
- Partnering with Us
Overview
Pharmacokinetics (PK) is the study of how drugs move through the body over time, including the processes of absorption, distribution, metabolism, and excretion. These processes collectively describe the body's response to the drug, which is crucial for understanding how the drug is absorbed into the bloodstream, distributed to various tissues and organs, metabolized into different compounds, and ultimately eliminated from the body. We are your preferred partner in the field of PK analysis. We provide a wide range of in vivo PK services to meet the different needs of customers. If you have any related needs, please feel free to contact us.
Significance of In Vivo PK Studies
In vivo PK studies are important in the drug development process as they provide valuable information on the pharmacokinetic profile of a drug, helping researchers understand how the drug behaves in the body and how it is cleared from the system. This information can be used to optimize dosing regimens, predict potential drug interactions, and assess the overall safety and efficacy of the drug.
Important Parameters of PK
Bioavailability (F)
Bioavailability refers to the fraction of an administered dose that reaches the systemic circulation in an unchanged form. It is typically expressed as a percentage and can vary depending on the route of administration (e.g., oral, intravenous). High bioavailability indicates efficient absorption of the drug.
Volume of Distribution (Vd)
The volume of distribution, also known as the apparent volume of distribution, is the apparent volume into which a drug disperses in order to produce the observed plasma concentration. It is a proportionality constant that relates the total amount of drug in the body to the plasma concentration of the drug at a given time.
Clearance (Cl)
Clearance is the rate at which a drug is removed from the body, typically by metabolism and/or excretion. It is expressed as volume per unit time (e.g., liters per hour) and reflects the body's ability to eliminate the drug. Clearance influences the drug's half-life and dosing regimen.
Half-life (t1/2)
The half-life of a drug is the time required for the concentration of the drug in the body to decrease by half. It provides information about the rate of elimination of the drug and is used to estimate the time it takes for a drug to reach steady-state concentration during repeated dosing.
Our Capabilities
We have the ability to study the following for you:
- Rank-ordering compounds/formulations
- Bioavailability and bioequivalence
- Dose proportionality (ascending dose)
- Dose linearity (multiple dose)
- In vivo drug interactions
- Tissue distribution (non-radioactive and radioactive)
- Toxicokinetics
- Non-compartmental and compartmental pharmacokinetics
- Pharmacodynamic and pharmacokinetic/pharmacodynamics modeling
- Preclinical vehicle screening
Partnering with Us
With outstanding performance, comprehensive services, and a firm commitment to quality and customer satisfaction, our company has become a leader in in vivo PK research. Whether you are a researcher, scientist, or a company seeking innovative solutions, you can trust us to deliver results that exceed your expectations. Contact us today to learn more about how we can support your research and development needs.