- Overview
- Our Peptide Technology Platforms
Overview
Peptides have received great attention in the field of biopharmaceuticals in recent years due to their favorable pharmacokinetic profile, high target specificity and low toxicity. With a wealth of experience and specialized equipment, our company has further expanded its service capabilities into the field of peptide drug development. We are equipped with a sophisticated peptide technology platform to provide one-stop services from custom peptide synthesis to peptide drug registration/filing and GMP production.
Our Peptide Technology Platforms
Solid-Phase Synthesis
Solid-phase peptide synthesis (SPPS) is a well-established technique widely used in peptide research and production. The advantages of solid-phase synthesis are mainly reflected in the fact that the initial reactants and products are connected to the solid-phase carrier, so all reactions can be carried out in a single reaction vessel, which is convenient for automatic operation.
Liquid-Phase Synthesis
Liquid-phase peptide synthesis (LPPS) is mainly used to synthesize short peptides, such as aspartame and oxytocin. Compared with solid-phase synthesis, LPPS has the advantages of more choices of protecting groups, low cost, and easy to scale up the synthesis.
Non-Classical Solid Phase Synthesis
Non-classical solid-phase synthesis represents an innovative approach within peptide technology platforms. By incorporating innovative strategies and techniques, non-classical solid-phase synthesis enables the synthesis of complex peptides with tailored structures and functionalities, driving innovation in peptide-based drug discovery and development.
Unnatural Amino Acid Synthesis
Unnatural amino acids are derivatives of natural amino acids with a variety of side chain groups and unique chemical properties. Unnatural amino acids are widely used in the field of biomedicine. They can be used to synthesize bioactive substances such as peptides, and can also be used for drug design and screening.
Others Technology Platforms
- Membrane concentration/purification
- Lyophilization
- Spray drying
- Click chemistry conjugation
- Glycoconjugation
- Cysteine-based site-specific conjugation
- Ion exchange chromatography
- Normal-phase preparative HPLC
- Reverse-phase preparative HPLC
- Other chromatography separation techniques