- Overview
- Comparison of Conventional EM and Cryo-EM
- Our Services
- Why Choose Us
Overview
Cryo-electron microscopy (cryo-EM) is an advanced imaging technique that allows scientists to view biological molecules with unprecedented clarity and detail. This technique has become the method of choice in biochemistry laboratories around the world, helping to accelerate the research process for drug discovery. Our cryo-EM services will help you rationalize drug design, understand ligand binding mechanisms, and optimize drug efficacy and specificity. If you are interested in our services, please contact our experts today. Let's work together to further develop your project.
Comparison of Conventional EM and Cryo-EM
Compared to conventional electron microscopy (EM), cryo-EM is a powerful tool for structural biology. A comparison of the features between the two is shown in the table below:
| Items | Conventional EM | Cryo-EM |
| Sample Preparation | Involves fixation, staining, dehydration and the use of chemical compounds or polymers | Involves flash-freezing techniques (vitrification) |
| Sample Integrity | Native structures may be altered and artifacts may appear | Native structures are well preserved |
| Resolution | High resolution (nm) | Higher resolution, near-atomic (Å) |
| Specimen Types | Ideal for cellular and subcellular structures | Ideal for biomolecules and complexes |
| Amount of Sample | Requires a large number of samples | Only very small amounts of biomolecules or complexes are needed |
Our Services
Our cryo-EM services are ideally suited to determine the structure of the following targets:
Single Proteins
Cryo-EM can determine the structures of individual proteins, providing insights into their fold, domain organization, and conformational dynamics.
Protein Complexes
Cryo-EM enables the visualization of multi-subunit protein complexes, such as ribosomes, proteasomes, chaperonins, and molecular motors, revealing their architectures and subunit arrangements.
Membrane Proteins
Cryo-EM can determine the structures of membrane proteins embedded in lipid bilayers, including ion channels, receptors, transporters, and enzymes, facilitating drug discovery and understanding of membrane protein function.
Why Choose Us
Our company is a specialized cryo-EM service provider. With our professional knowledge and advanced technology, we are able to provide you with customized solutions. We strive for excellence and are committed to giving our clients the confidence to advance their research goals and achieve scientific breakthroughs.