- Overview
- Importance
- Our Services
- FAQs
Overview
Genetic toxicology is a branch of toxicology that focuses on studying the potential for chemicals or physical agents to cause damage to DNA and induce mutations, which can lead to adverse health effects such as cancer or genetic disorders. With extensive experience and technological capabilities, our company is deeply involved in the field of genetic toxicology, designing and conducting genotoxicity studies to provide critical data for safety assessment.
The Importance of Genetic Toxicology
The discipline's importance stems from its role in safeguarding human health. Essentially, agents with genotoxic effects can induce a variety of dangerous consequences, including mutations, chromosomal aberrations and genetic recombination. Understanding these threats can help predict and prevent potential genetic damage, which will have a profound impact on human well-being.
Our Services
In-Vitro Toxicology Services
Our company delivers comprehensive in vitro genetic toxicology tests to evaluate the genotoxic potential of substances. These tests include the in vitro chromosomal aberration test, the in vitro micronucleus test, the mouse lymphoma test, and the bacterial reverse mutation test. Our tests use cellular systems under controlled laboratory conditions to assess the potential cytogenetic effects of genotoxic substances.
In-Vivo Toxicology Services
We also offer in vivo genotoxicity testing to provide a comprehensive understanding of the genotoxic potential of substances in living organisms. These services include in vivo micronucleus test, in vivo alkaline comet test and in vivo chromosomal aberration test. Our tests are performed in living organisms and are therefore more biologically relevant.
Data Interpretation and Regulatory Support
For most people, the raw data may not be decipherable. Therefore, our services are not limited to data generation. We also provide robust data interpretation services so that our clients can better understand genotoxic risk. In addition, we offer regulatory support to ensure our clients' genetic toxicology studies are aligned with the guidelines laid down by regulating authorities like FDA and EMA.
Potential genotoxic effects pose a serious threat to human health and drug development, and utilizing our genetic toxicology services allows for early identification and mitigation of these risks. Whether it is in vitro, in vivo toxicity testing, or regulatory support, our services are designed to meet the specific needs of our clients.
Frequently Asked Questions (FAQs) About Genetic Toxicology
What is micronucleus test?
The micronucleus test is a method used to evaluate genetic damage or chromosomal abnormalities in cells. It involves counting the number of micronuclei present in a cell, which are small fragments of chromosomes that were not incorporated into the nucleus during cell division. An increase in the number of micronuclei can indicate DNA damage or chromosomal instability, which may be caused by exposure to genotoxic substances such as radiation, chemicals, or certain drugs. The micronucleus test is often used in toxicology and genotoxicity studies to assess the potential carcinogenic effects of various substances.
What is chromosomal aberration test?
The chromosomal aberration test is a valuable tool for assessing the genotoxicity of substances. Chromosomal aberrations include deletions, duplications, inversions, translocations, or other changes to the genetic material in a person's cells. These aberrations can be associated with genetic disorders, birth defects, and certain types of cancer.
What is bacterial reverse mutation test?
The bacterial reverse mutation test, commonly known as the Ames test, is a widely used assay in genetic toxicology to identify potential mutagens and assess their genotoxicity. It provides valuable data on the ability of chemicals to induce point mutations in bacterial DNA.